Maximal aerobic capacity (VO 2max), which while directly testing cardiovascularįitness and integrity also represents a combination of other physiologic components. A major predictor of functional capacity is

Importantly, a direct relationship between functional capacity and survival is aĬornerstone of general medicine theory.

Increase functional capacity (considered in specific detail in the aging section). Functional capacity is pliable declining rapidly withĮxtreme physical inactivity or more slowly with aging, while preventing inactivity can If an external stress disrupts homeostasis beyond an organism'sįunctional capacity, life may not be sustained. System, or body to maintain homeostasis within their narrow limits of survival in response We define “functional capacity” as the ability of a cell, organ,

That chronic disease need not be an inevitable outcome during life. In addition, physical activity primarily prevents, or delays, chronic diseases, implying Taken together, conclusiveĮvidence exists that physical inactivity is one important cause of most chronic diseases. Substantial decreases in both total and quality years of life. Rapidly maladapts to insufficient physical activity, and if continued, results in The article ends withĬonsideration of deterioration of risk factors in longer-term sedentary groups clinicalĬonsequences of inactive childhood/adolescence and public policy. Gestational diabetes, preeclampsia, polycystic ovary syndrome, erectile dysfunction, pain,ĭiverticulitis, constipation, and gallbladder diseases]. Peripheral artery disease, hypertension, stroke, congestive heart failure, endothelialĭysfunction, arterial dyslipidemia, hemostasis, deep vein thrombosis, cognitiveĭysfunction, depression and anxiety, osteoporosis, osteoarthritis, balance, boneįracture/falls, rheumatoid arthritis, colon cancer, breast cancer, endometrial cancer, Prediabetes, type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease, (VO 2max), sarcopenia, metabolic syndrome, obesity, insulin resistance, [Accelerated biological aging/premature death, low cardiorespiratory fitness Next, physicalĪctivity/exercise is examined as primary prevention against 35 chronic conditions and specificity of adaptations to type of training. Physical activity and inactivity mechanisms differ gene-environment interaction The initial third of the article considers:Īctivity and prevention definitions historical evidence showing physical inactivity isĭetrimental to health and normal organ functional capacities cause vs. Chronic diseases are major killers in the modern era.

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